Aim:  Investigation the spatiotemporal noradrenaline (NA) dynamics during a stress-induced dystonic episode in an episodic ataxia type 2 (EA2) mouse cerebellum

Noradrenaline is a key monoamine released throughout the brain to regulate a plethora of functions including arousal, attention, cognition and stress-related processes via their adrenergic receptors (AR). Understanding the spatiotemporal dynamics of NA in different neurons under stressful conditions is critical for the further development of therapeutic options for individuals suffering from impaired cognition and arousal and a number of stress-related psychiatric and neurodegenerative diseases including dystonia.

 

 10 selected publications 

• Bohne P, Volkmann A, Schwarz MK, Mark MD (2022) Deletion of the P/Q-type calcium channel from serotonergic neurons drives male aggression in mice. Journal of Neuroscience 19 July 2022, JN-RM-0204-22; DOI: https://doi.org/10.1523/JNEUROSCI.0204-22.2022  

• Schwitalla JC, Pakusch J, Mücher B, Brückner A, Depke DA, Fenzl T, De Zeeuw CI, Kros L, Hoebeek FE, Mark MD. (2022) Controlling absence seizures from the cerebellar nuclei via activation of the G q signaling pathway. Cell Mol Life Sci 2022 Mar 19;79(4):197. doi: 10.1007/s00018-022-04221-5.

• Karapinar R, Schwitalla JC, Eickelbeck D, Pakusch J, Mücher B, Grömmke M, Surdin T, Knöpfel T, Mark MD*, Siveke I, Herlitze S. (2021) Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks. Nature Commun. 12(1):4488. *co-corresponding author

• Miao QL, Herlitze S, Mark MD, Noebels JL (2020) Adult Loss of Cacna1a in Mice Recapitulates Childhood Absence Epilepsy by Distinct Thalamic Bursting Mechanisms. Brain. 143(1): 161-174.

• Mark MD, Wollenweber P, Gesk A, Kösters K, Batzke K, Janoschka C, Maejima T, Han J, Deneris ES, Herlitze S (2019) RGS2 Drives Male Agression in Mice via the Serotonergic System. Commun Biology. 2: 373.

• Fekete A, Nakamura Y, Yang YM, Herlitze S, Mark MD, DiGregorio DA, Wang LY (2019) Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules. Nature Comm. 10(1): 826.

• Mark MD, Krause M, Boele HJ, Kruse W, Pollok S, Kuner T, Dalkara D, Koekkoek S, De Zeeuw CI, Herlitze S. (2015) Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity. J. Neurosci., 35(23): 8882-95.

• Maejima T, Wollenweber P, Teusner LUC, Noebels JL, Herlitze S and Mark MD. (2013) Postnatal Loss of P/Q-type Channels Confined to Rhombic Lip Derived Neurons Alters Synaptic Transmission at the Parallel Fiber to Purkinje Cell Synapse and Replicates Genomic Cacna1a Mutation Phenotype of Ataxia and Seizures in Mice. J Neurosci., 33(12): 5162-74.

• Mark MD, Maejima T, Kuckelsberg D, Yoo JW, Hyde RA, Shah V, Gutierrez D, Moreno RL, Kruse W, Noebels JL, Herlitze S. (2011) Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations. J Neurosci., 31(11): 4311-26.

• Han J, Mark MD, Li X, Xie M, Waka S, Rettig J and Herlitze S (2006) RGS2 Determines Short-Term Synaptic Plasticity in Hippocampal Neurons by Regulating Gi/o-Mediated Inhibition of Presynaptic Ca2+ Channels. Neuron, 51(5): 575-86.