Head of Optical Imaging Group
Institute: Institut für Neuroinformatik Ruhr-Universität Bochum
44780 Bochum, Germany
Phone: +49 234 32 27845
Mail: Dirk.Jancke@rub.de
Website: https://jancke-lab.de/

 

Aim:  Enhancing visual cortical plasticity and restoration of retinal function by means of optogenetic tools of 5-HT receptor signals

Growth and loss of neuronal elements are important common features of postnatal plastic capacities of the brain (Recanzone et al., 1992; Keck et al., 2008; Berry and Nedivi, 2017). Thus, even though the coarse structure and function of the adult brain appears relatively stable, use and disuse as well as damage can reinstall functional as well as structural mechanisms of neuronal plasticity. Previous work that investigated adult visual cortical plasticity have focused on the role of neuronal excitability for the functional dynamics of reorganization in the adult visual cortex making use of a retinal lesion model in combination with optical imaging in cats and rats (Das and Gilbert, 1995; Giannikopoulos and Eysel, 2006; Palagina et al., 2009; Kozyrev et al., 2014, 2018). These in vivo studies showed that cortical remodelling is associated with spatiotemporal pattern of strongly increased spontaneous and evoked activity enabling targeted rewiring of the cortical circuitry.

 

 10 selected publications 

• Jancke, D., Herlitze, S., Kringelberg, M.L., and Deco, G. Bridging the gap between single receptor type activity and whole brain dynamics. FEBS J., in press. Published online: doi: 10.1111/febs.15855

• Eickelbeck, D., Karapinar, R., Jack, A., Suess, S.T., Barzan, R., Azimi, Z., Surdin, T., Grömmke, M., Mark, M.D., Gerwert, K., Jancke, D., Wahle, P., Spoida, K. and Herlitze, S. (2019) and receptor trafficking in GPCR-specific domains. Commun Biol. 2:60. doi: 10.1038/s42003- 019-0292-y. eCollection 2019.

• Kozyrev, V., Staadt, R., Eysel, U.T., and Jancke, D. (2018). TMS-induced neuronal plasticity enables targeted remodeling of visual cortical maps. Proc. Natl. Acad. Sci., USA 115: 6476-6481.

• Rekauzke, S., Nortmann, N., Staadt, R., Hock, H.S., Schöner, G., and Jancke, D. (2016). Temporal asymmetry in dark-bright processing initiates propagating activity across primaryÊ visual cortex. J. Neuroscience 36: 1902-1913.

• Nortmann, N., Rekauzke, S., Onat, S., Konig, P., and Jancke, D. (2015). Primary visual cortex represents the difference between past and present. Cereb. Cortex 25: 1427-1440.

• Kozyrev, V., Eysel, U.T., and Jancke, D. (2014). Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics. Proc. Natl. Acad. Sci., USA, 111: 13553-13558.

• Palagina, G., Eysel, U.T., and Jancke, D. (2009). Strengthening of lateral activation in adult rat visual cortex after retinal lesions captured with voltage-sensitive dye imaging in vivo. Proc. Natl. Acad. Sci., USA, 106: 8743-8747.

• Jancke, D., Chavane, F., Naaman, S., and Grinvald, A. (2004). Imaging cortical correlates of illusion in early visual cortex. Nature 428: 423-426.

• Jancke, D. (2000). Orientation formed by a spot's trajectory: a two-dimensional population approach in primary visual cortex. J. Neuroscience 20: RC86.

• Jancke, D., Erlhagen, W., Dinse, H.R., Akhavan, A.C., Giese, M., Steinhage, A., and Schöner, G. (1999). Parametric population representation of retinal location: neuronal interaction dynamics in cat primary visual cortex. J. Neuroscience 19: 9016-9028.