Department of General Zoology and Neurobiology
Institute: Institute for Biology and Biotechnology Faculty of Biology and Biotechnology
44780 Bochum, Germany
Phone: +49 234 32 28343
Mail: ida.siveke@rub.de
Website: www.ruhr-uni-bochum.de/neurobiol/
Primary Supervisor – PD Dr. Ida Siveke
Co-Supervisor – Prof. Dr. Dirk Jancke
Aim: Optogenetic targeting of dopamine signaling in the mouse retina and decreasing the burden of vision impairments following retina degeneration
Dopamine is a key neuromodulator in the brain and in particular in the retins. Within the retina dopamine is synthesized and released from amacrine and interplexiform cells. (Popova, 2014). Dopamine has been described as one of the most important retinal neuromodulators modulating neuronal plasticity during development and in adult animals for example during light adaptation (for review (Roy and Field, 2019; Witkovsky, 2004)). Histological studies in rd1 mouse, a mouse model established for human retina degeneration, showed that dopamine antagonists or dopamine depletion by destroying dopaminergic retinal neurons blocked photoreceptor degeneration in retinal organ culture (Ogilvie and Speck, 2002). In the modulated degeneration especially dopamine 2 receptors (D2R) are reported to be involved. D2Rs are couped to Gi/o signaling and are expressed in ganglion cells and in particular in the dopaminergic amacrine cells. Here they act as autoreceptors, inhibiting or reducing dopamine release and controlling photoreceptor coupling (Goel and Mangel, 2021; Ribelayga et al., 2008). Until now the protection of photoreceptor degeneration by modulation of dopamine signaling could not been demonstrated in vivo (Ogilvie et al., 2009) majorly due to technical limitations of pharmacological drug application on the small postnatal mouse eye over long time periods. Thus, new methods must be developed to understand the dopamine signaling cascades involved in retinal degeneration and finally to delay progression of blindness in the mouse model.
10 selected publications
Surdin, T., Preissing, B., Rohr, L., Grömmke, M., Böke, H., Barcik, M., Azimi, Z., Jancke, D., Herlitze, S., Mark, M.D., Siveke, I. (2022). Optogenetic activation of mGluR1 signaling in the cerebellum induces synaptic plasticity. iScience. 26(1). DOI: 10.1016/j.isci.2022.105828.
Karapinar R, Schwitalla JC, Eickelbeck D, Pakusch J, Mücher B, Grömmke M, Surdin T, Knöpfel T, Mark MD, Siveke I, Herlitze S. (2021) Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks. Nature Commun. 12(1):4488. doi: 10.1038/s41467-021-24718-0. PMID: 34301944
Siveke I, Myoga MH, Grothe B, Felmy F. (2021) Ambient noise exposure induces long-term adaptations in adult brainstem neurons. Sci Rep 11, doi:10.1038/s41598-021- 5139.
Siveke I, Lingner A, Ammer JJ, Gleiss SA, Grothe B, Felmy F.(2019) A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure Level. Front Neural Circuits doi:10.3389/fncir.2019.00008. 84230-9. 13, 13-18.
Siveke I, Ammer JJ, Gleiss SA, Grothe B, Leibold C, Felmy F. (2018) Electrogenic N- methyl-D-aspartate receptor signaling enhances binaural responses in the adult brainstem. Eur J Neurosci 47, 858-865. doi:10.1111/ejn.13859.
Stange A, Myoga MH, Lingner A, Ford MC, Alexandrova O, Felmy F, Pecka M, Siveke I, and Grothe B. (2013) Adaptation in sound localization: from GABAB receptor-mediated synaptic modulation to perception. Nature Neurosci 16(12):1840-7. doi:10.1038/nn.3548.
Siveke I, Leibold C, Kaiser K, Grothe B, and Wiegrebe L. (2010) Level dependent latency shifts quantified through binaural processing. J Neurophysiol 104(4): 2224-35. doi:10.1152/jn.00392.2010.
Siveke I, Ewert SD, Grothe B, Wiegrebe L. (2008) Perceptual and Physiological Evidence for Fast Binaural Processing. J Neurosci 28(9): 2043Ð2052. doi:0.1523/JNEUROSCI.4488-07.2008.
Siveke I, Leibold C, Grothe B. (2007) Spectral composition of concurrent noise affects neuronal sensitivity to interaural time differences of tones in the dorsal nucleus of the lateral lemniscus. J Neurophysiol 98(5):2705-271. doi: 10.1152/jn.00275.2007.
Siveke I, Pecka M, Seidl AH, Baudoux S, Grothe B. (2006) Binaural response properties of low-frequency neurons in the gerbil dorsal nucleus of the lateral lemniscus. J Neurophysiol 96(3):1425-40. doi:10.1152/jn.00713.2005.