Prof. Dr. Stefan Herlitze - Publikationen

2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1990-1994



Süß ST, Olbricht LM, Herlitze S, Spoida K. (2022)
Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway.
Transl Psychiatry. 2022 Nov 19. DOI: 10.1038/s41398-022-02252-x.

Surdin T, Preissing B, Rohr L, Grömmke M, Böke H, Barcik M, Azimi Z, Jancke D, Herlitze S, Mark MD, Siveke I (2022)
Optogenetic activation of mGluR1 signaling in the cerebellum induces synaptic plasticity.
iScience 2022 Dec 17;26(1):105828, DOI: 10.1016/j.isci.2022.105828

Mark MD, Schwitalla JC, Herlitze S (2022)
Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengers.
Part II, p161-194. Book Chapter in: Zamponi GW, Weiss N (eds), Voltage-Gated Calcium Channels
Book Chapter



Karapinar R*, Schwitalla JC*, Eickelbeck D*, Pakusch J, Mücher B, Grömmke M, Surdin T, Knöpfel T, Mark MD*, Siveke I, Herlitze S*(2021)
Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks.
Nat Commun. 2021 Jul 23;12(1):4488. doi: 10.1038/s41467-021-24718-0. PMID: 34301944 *equal contributions

Hamad MIK, Jbara A, Rabaya O, Petrova P, Daoud S, Melliti N, Meseke M, Lutz D, Petrasch-Parwez E, Schwitalla JC, Mark MD, Herlitze S, Reiss G., Herz J, Förster E (2021)
Reelin modulates GABAB receptor function in the neocortex.
J. of Neurochemistry. DOI: 10.1111/jnc.14990



Bres EE, Safina D, Müller J, Bedner P, Yang H, Helluy X, Shchyglo O, Jansen S, Mark MD, Esser A, Steinhäuser C, Herlitze S, Pietrzik CU, Sirko S, Manahan-Vaughan D, Faissner A (2020)
Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures.
Glia. 2020 Dec;68(12):2517-2549. doi: 10.1002/glia.23869. Epub 2020 Jun 24. PMID: 32579270

Simon CJ, Sahel JA, Duebel J, Herlitze S, Dalkara D (2020)
Opsins for vision restoration.
Biochem. Biophys. Res. Commun. doi:10.1016/j.bbrc.2019.12.117.

Azimi Z, Barzan R, Spoida K, Surdin T, Wollenweber P, Mark MD, Herlitze S, Jancke D (2020)
Separable Gain Control of Ongoing and Evoked Activity in the Visual Cortex by Serotonergic Input
PMID: 32252889 , PMICD: PMC7138610, DOI: 10.7554/eLife.53552

Marquitan M, Ruff A, Bramini M, Herlitze S, Mark MD, Schuhmann W (2020)
Polymer/Enzyme-modified HF-etched carbon nanoelectrodes for single-cell analysis.
Bioelectrochemistry. Bioelectrochemistry. DOI: 10.1016/j.bioelechem.2020.107487

Hellinger J, Jägers P, Spoida K, Weiss LC, Mark MD, Herlitze S (2020)
Analysis of the territorial aggressice behavior of the bioluminescent flashlight fish Photoblepharon steinitizi in the Red Sea.
Front. Mar. Sci. 7:78. doi: 10.3389/fmars.2020.00078

Miao QL, Herlitze S, Mark MD, Noebels JL (2020)
Adult Loss of Cacna1a in Mice Recapitulates Childhood Absence Epilepsy by Distinct Thalamic Bursting Mechanisms. Brain. 143(1): 161-174.

Marquitan M, Mark MD, Ernst A, Muh A, Herlitze S, Ruff A and Schuhmann W (2020)
Glutamate detection at the cellular level by means of polymer/enzyme multilayer modified carbon nanoelectrodes. Journal of Materials Chemistry B. DOI: 10.1039/c9tb02461a



Mark MD, Wollenweber P, Gesk A, Kösters K, Batzke K, Janoschka C, Maejima T, Han J, Deneris ES, Herlitze S. (2019)
RGS2 drives male aggression in mice via the serotonergic system.
Commun Biol. 2019 Oct 11;2:373. doi: 10.1038/s42003-019-0622-0. eCollection 2019.

Eickelbeck D, Rudack T, Tennigkeit SA, Surdin T, Karapinar R, Schwitalla JC, Mücher B, Shulman M, Scherlo M, Althoff P, Mark MD, Gerwert K, Herlitze S. (2019)
Lamprey Parapinopsin ("UVLamP"): a Bistable UV-Sensitive Optogenetic Switch for Ultrafast Control of GPCR Pathways.
Chembiochem.. doi:10.1002/cbic.201900485.

Bohne P, Schwarz MK, Herlitze S, Mark MD. (2019)
A New Projection From the Deep Cerebellar Nuclei to the Hippocampus via the Ventrolateral and Laterodorsal Thalamus in Mice.
Front Neural Circuits. 2019 Aug 9;13:51. doi: 10.3389/fncir.2019.00051. eCollection 2019.

Tennigkeit SA, Karapinar R, Rudack T, Dreier MA, Althoff P, Eickelbeck D, Surdin T, Grömmke M, Mark MD, Spoida K, Lübben M, Höweler U, Herlitze S, Gerwert K. (2019)
Design of an Ultrafast G Protein Switch Based on a Mouse Melanopsin Variant.
Chembiochem. 2019 Jul 15;20(14):1766-1771. doi: 10.1002/cbic.201900110. Epub 2019 Jun 18.

Eickelbeck D, Karapinar R, Jack A, Suess ST, Barzan R, Azimi Z, Surdin T, Grömmke M, Mark MD, Gerwert K, Jancke D, Wahle P, Spoida K, Herlitze S. (2019)
CaMello-XR enables visualization and optogenetic control of Gq/11 signals and receptor trafficking in GPCR-specific domains.
Commun Biol. 2019 Feb 14;2:60. doi: 10.1038/s42003-019-0292-y. eCollection 2019. PMID: 30793039

Fekete A, Nakamura Y, Yang YM, Herlitze S, Mark MD, DiGregorio DA, Wang LY. (2019)
Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules.
Nat Commun. 2019 Feb 18;10(1):826. doi: 10.1038/s41467-019-08452-2. PMID: 30778063



Mark MD, Donner M, Eickelbeck D, Stepien J, Nowrousian M, Kück U, Paris F, Hellinger J, Herlitze S. (2018)
Visual tuning in the flashlight fish Anomalops katoptron to detect blue, bioluminescent light.
PLoS One. 2018 Jul 11;13(7):e0198765. doi: 10.1371/journal.pone.0198765. eCollection 2018. PMID: 29995896



Soya S, Takahashi TM, McHugh TJ, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T. (2017)
Orexin modulates behavioral fear expression through the locus coeruleus.
Nat Commun. 2017 Nov 20;8(1):1606. doi: 10.1038/s41467-017-01782-z.

Kastanenka KV, Herlitze S, Boyden ES, Tsai L, Bacskai BJ (2017)
Optogenetics Shed Light on Alzheimer’s Disease.
EC Neurology ECO.01 (2017): 27-29

Hasegawa E, Maejima T, Yoshida T, Masseck OA, Herlitze S, Yoshioka M, Sakurai T, Mieda M. (2017)
Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity.
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3526-E3535. doi: 10.1073/pnas.1614552114. Epub 2017 Apr 10.
PMID: 28396432

Hellinger J, Jägers P, Donner M, Sutt F, Mark MD, Senen B, Tollrian R, Herlitze S. (2017)
The Flashlight Fish Anomalops katoptron Uses Bioluminescent Light to Detect Prey in the Dark.
PLoS One. 2017 Feb 8;12(2):e0170489. doi: 10.1371/journal.pone.0170489. eCollection 2017.
PMID: 28178297

Mark MD, Schwitalla JC, Groemmke M, Herlitze S. (2017)
Keeping Our Calcium in Balance to Maintain Our Balance.
Biochem Biophys Res Commun. Invited Review. 483: 1040 -1050.



Marquitan M, Clausmeyer J, Actis P, Córdoba AL, Korchev Y, Mark MD, Herlitze S and Schuhmann W (2016)
Intracellular Hydrogen Peroxide Detection with Functionalised Nanoelectrodes.
ChemElectroChem. 24 AUG 2016 | DOI: 10.1002/celc.201600390.

Spoida K, Eickelbeck D, Karapinar R, Eckhardt, T, Mark MD, Jancke D, Ehinger BV, König P, Dalkara D, Herlitze S, Masseck OA. (2016)
Melanopsin Variants as Intrinsic Optogenetic On and Off Switches for Transient versus Sustained Activation of G Protein Pathways.
Current Biology 26 (9), 1206–1212

Bomben VC, Aiba I, Qian J, Mark MD, Herlitze S, Noebels JL (2016)
Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.
J Neurosci. 2016 Jan 13;36(2):405-18. doi: 10.1523/JNEUROSCI.2555-15.2016.
PMID: 26758833



Mark MD, Krause M, Boele HJ, Kruse W, Pollok S, Kuner T, Dalkara D, Koekkoek S, De Zeeuw CI, Herlitze S. (2015)
Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity.
J Neurosci. Jun 10;35(23):8882-8895. doi: 10.1523/JNEUROSCI.0891-15.2015.

Aarse J, Herlitze S, Manahan-Vaughan D (2015)
The requirement of BDNF for hippocampal synaptic plasticity is experience-dependent.
Hippocampus. 2015 Dec 10. doi: 10.1002/hipo.22555. [Epub ahead of print]
PMID: 26662461

Lux V, Masseck OA, Herlitze S, Sauvage MM (2015)
Optogenetic Destabilization of the Memory Trace in CA1: Insights into Reconsolidation and Retrieval Processes.
Cereb Cortex. 2015 Nov 29. pii: bhv282. [Epub ahead of print]
PMID: 26620265



Masseck OA, Mark MD, Herlitze S (2014)
Use of Optogenetic Approaches to Control Intracellular Signaling of G Protein-Coupled Receptors. G-Protein Coupled Receptor Genetics.
Methods in Pharmacology and Toxicology pp. 149-160. Springer Verlag Book Chapter.

Kruse W, Krause M, Aarse J, Mark MD, Manahan-Vaughan D, Herlitze S. (2014)
Optogenetic Modulation and Multi-Electrode Analysis of Cerebellar Networks In Vivo.
DOI: 10.1371/journal.pone.0105589

Spoida K, Masseck OA, Deneris ES, Herlitze S. (2014)
Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice.
Proc. Natl. Acad. Sci. U S A. 111(17):6479-84.
doi: 10.1073/pnas.1321576111

Masseck OA, Spoida K, Dalkara D, Maejima T, Rubelowski JM, Wallhorn L, Deneris ES, Herlitze S (2014)
Vertebrate Cone Opsins Enable Sustained and Highly Sensitive Rapid Control of Gi/o Signaling in Anxiety Circuitry
Neuron, 18 (6):1263-1273,doi:10.1016/j.neuron.2014.01.041.
Abstract + Video



Maejima T, Wollenweber P, Teusner LUC, Noebels JL, Herlitze S, Mark MD. (2013)
Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to Purkinje Cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice.
The Journal of Neuroscience, doi: 10.1523/JNEUROSCI.5442-12.2013

Maejima T, Masseck OA, Mark MD, Herlitze S (2013)
Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channels.
Front Integr Neurosci. 23:7-40, doi: 10.3389/fnint.2013.00040



Masseck OA, Rubelowski JM, Spoida K, Herlitze S. (2011)
Light- and drug-activated G-protein-coupled receptors to control intracellular signalling.
Exp Physiol. 2011 Jan;96(1):51-56.

Mark M, Maejima T, Kuckelsberg D, Yoo J, Hyde R, Shah V, Gutierrez D, Moreno R, Kruse W, Noebels J , Herlitze S. (2011)
Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1A mutations.
J. Neurosci. 31:4311-4326.

Gutierrez DV, Mark MD, Masseck O, Maejima T, Kuckelsberg D, Hyde RA, Krause M, Kruse W, Herlitze S.(2011)
Optogenetic control of motor coordination by Gi/o protein-coupled vertebrate rhodopsin in cerebellar purkinje cells.
J Biol Chem. 286:25848-25858.



Oh E, Maejima T, Liu C, Deneris ES, Herlitze S. (2010)
Substitution of 5HT1A receptor signaling by light-activated G protein coupled receptors.
J. Biol. Chem. 2010 Oct 1;285:30825-30836. doi:10.1074/jbc.M110.147298.

Liu C, Maejima T, Wyler S, Casadeus G, Herlitze S, Deneris ES. (2010)
Pet-1 is required across different stages of life to regulate serotonergic function.
Nature Neuroscience 2010 Oct;13(10):1190-1198.



Alilain WJ, Li X, Horn KP, Dhingra R, Dick TE, Herlitze S, Silver J. (2008)
Light-induced rescue of breathing after spinal cord injury.
J Neurosci. 2008 Nov 12;28(46):11862-11870.

Rong YP, Aromolaran AS, Bultynck G, Zhong F, Li X, McColl K, Matsuyama S, Herlitze S, Roderick HL, Bootman MD, Mignery GA, Parys JB, De Smedt H, Distelhorst CW. (2008)
Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals.
Mol Cell. 2008 Jul 25;31(2):255-265.



Xie M, Li X, Han J, Vogt DL, Wittemann S, Mark MD, Herlitze S. (2007)
Facilitation versus depression in cultured hippocampal neurons determined by targeting of Ca2+ channel Cavbeta4 versus Cavbeta2 subunits to synaptic terminals.
J Cell Biol. 2007 Jul 30;178(3):489-502

Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL. (2007)
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-5168. Epub 2007 Mar 2.

Herlitze S, Landmesser LT. (2007)
New optical tools for controlling neuronal activity.
Curr Opin Neurobiol. 2007 Feb;17(1):87-94. Epub 2006 Dec 15. Review.



Han J, Mark MD, Li X, Xie M, Waka S, Rettig J, Herlitze S. (2006)
RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi/o-mediated inhibition of presynaptic Ca2+ channels.
Neuron. 2006 Sep 7;51(5):575-586.



Li X, Gutierrez DV, Hanson MG, Han J, Mark MD, Chiel H, Hegemann P, Landmesser LT, Herlitze S. (2005)
Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin.
Proc Natl Acad Sci U S A. 2005 Dec 6; 102(49):17816-17821, doi:10.1073/pnas.0509030102..

Scott MM, Wylie CJ, Lerch JK, Murphy R, Lobur K, Herlitze S, Jiang W, Conlon RA, Strowbridge BW, Deneris ES. (2005)
A genetic approach to access serotonin neurons for in vivo and in vitro studies.
Proc Natl Acad Sci U S A. 2005 Nov 8; 102(45):16472-16477.

Li X, Hümmer A, Han J, Xie M, Melnik-Martinez K, Moreno RL, Buck M, Mark MD, Herlitze S. (2005)
G protein beta2 subunit-derived peptides for inhibition and induction of G protein pathways. Examination of voltage-gated Ca2+ and G protein inwardly rectifying K+ channels.
J Biol Chem. 2005 Jun 24; 280(25):23945-23959.

Herlitze S, Mark, MD. (2005)
Distribution and targeting of Ca2+ channels. Book Title:Voltage-gated Calcium Channels,
Editor: Gerald Zamponi, Chapter 7, 113-140, Kluwer Academic Plenum Publ., ISBN: 0-306-47840-4.



Kurata HT, Phillips LR, Rose T, Loussouarn G, Herlitze S, Fritzenschaft H, Enkvetchakul D, Nichols CG, Baukrowitz T. (2004)
Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis.
J Gen Physiol. 2004 Nov; 124(5):541-554.



Herlitze S, Xie M, Han J, Hummer A, Melnik-Martinez KV, Moreno RL, Mark MD. (2003)
Targeting mechanisms of high voltage-activated Ca2+ channels.
J Bioenerg Biomembr. 2003 Dec; 35(6):621-637.

Hümmer A, Delzeith O, Gomez SR, Moreno RL, Mark MD, Herlitze S. (2003)
Competitive and synergistic interactions of G protein beta(2) and Ca(2+) channel beta(1b) subunits with Ca(v)2.1 channels, revealed by mammalian two-hybrid and fluorescence resonance energy transfer measurements.
J Biol Chem. 2003 Dec 5; 278(49):49386-49400.



Herlitze S, Zhong H, Scheuer T, Catterall WA. (2001)
Allosteric modulation of Ca2+ channels by G proteins, voltage-dependent facilitation, protein kinase C, and Ca(v)beta subunits.
Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4699-4704.



Mark MD, Wittemann S, Herlitze S. (2000)
G protein modulation of recombinant P/Q-type calcium channels by regulators of G protein signalling proteins.
J Physiol. 2000 Oct 1; 528 Pt 1:65-77.

Mark MD, Herlitze S. (2000)
G-protein mediated gating of inward-rectifier K+ channels.
Eur J Biochem. 2000 Oct; 267(19):5830-5836.

Mark MD, Ruppersberg JP, Herlitze S. (2000)
Regulation of GIRK channel deactivation by Galpha(q) and Galpha(i/o) pathways.
Neuropharmacology. 2000 Sep; 39(12):2360-2373.

Wittemann S, Mark MD, Rettig J, Herlitze S. (2000)
Synaptic localization and presynaptic function of calcium channel beta 4-subunits in cultured hippocampal neurons.
J Biol Chem. 2000 Dec 1; 275(48):37807-37814.



Herlitze S, Ruppersberg JP, Mark MD. (1999)
New roles for RGS2, 5 and 8 on the ratio-dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes.
J Physiol. 1999 Jun 1; 517 ( Pt 2):341-352.



Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, Ruppersberg JP, Fakler B. (1998)
PIP2 and PIP as determinants for ATP inhibition of KATP channels.
Science. 1998 Nov 6; 282(5391):1141-1144.



Herlitze S, Hockerman GH, Scheuer T, Catterall WA. (1997)
Molecular determinants of inactivation and G protein modulation in the intracellular loop connecting domains I and II of the calcium channel alpha1A subunit.
Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1512-1516.



Herlitze S, Garcia DE, Mackie K, Hille B, Scheuer T, Catterall WA. (1996)
Modulation of Ca2+ channels by G-protein beta gamma subunits.
Nature. 1996 Mar 21; 380(6571):258-262

Herlitze S, Villarroel A, Witzemann V, Koenen M, Sakmann B. (1996)
Structural determinants of channel conductance in fetal and adult rat muscle acetylcholine receptors.
J Physiol. 1996 May 1;492 ( Pt 3):775-787.



Fakler B, Herlitze S, Amthor B, Zenner HP, Ruppersberg JP. (1994)
Short antisense oligonucleotide-mediated inhibition is strongly dependent on oligo length and concentration but almost independent of location of the target sequence.
J Biol Chem. 1994 Jun 10;269(23):16187-16194.



Herlitze S, Raditsch M, Ruppersberg JP, Jahn W, Monyer H, Schoepfer R, Witzemann V. (1993)
Argiotoxin detects molecular differences in AMPA receptor channels.
Neuron. 1993 Jun;10(6):1131-1140.



Villarroel A, Herlitze S, Witzemann V, Koenen M, Sakmann B. (1992)
Asymmetry of the rat acetylcholine receptor subunits in the narrow region of the pore.
Proc Biol Sci. 1992 Sep 22;249(1326):317-324.



Villarroel A, Herlitze S, Koenen M, Sakmann B. (1991)
Location of a threonine residue in the alpha-subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel.
Proc Biol Sci. 1991 Jan 22;243(1306):69-74.



Herlitze S, Koenen M. (1990)
A general and rapid mutagenesis method using polymerase chain reaction.
Gene. 1990 Jul 2;91(1):143-147.