Prof. Dr. Melanie Mark - Publikationen

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2007 | 20062005 | 2003 | 2000 | 19991997 | 1996 | 1995 |


Batsikadze G*, Pakusch J*, Klein M, Ernst TM, Thieme A, Nicksirat SA, Steiner KM, Nio E, Genc E, Maderwald S, Deuschl C, Merz CJ, Quick HH, Mark MD*, Timmann D* (2024)
Mild deficits in fear learning: Evidence from humans and mice with cerebellar cortical degeneration.
eNeuro. 2024 Jan 4:ENEURO.0365-23.2023. doi: 10.1523/ENEURO.0365-23.2023. Online ahead of print.
*Equal contribution.

Krause F, Schmidtke K, de Vasconcelos MF, Schmidt D, Cansiz B, Theisen F, Mark MD, Rybarski MO.
A shedding analysis after AAV8 CNS injection revealed fragmented viral DNA without evidence of functional AAV particles in mice.
Gene Ther. 2024 Mar 12. doi: 10.1038/s41434-024-00447-z. Epub ahead of print.

Deane KE, Klymentiev R, Heck J, Mark MD, Ohl FW, Heine M, Happel MFK (2024)
Inhibiting presynaptic calcium channel motility in the auditory cortex suppresses synchronized input processing.
Front. Cell. Neurosci., 10 April 2024 Sec. Cellular Neurophysiology Volume 18 – 2024
doi: 10.3389/fncel.2024.1369047

Piotrowski D, Clemensson EKH, Nguyen HP, Mark MD (2024)
Phenotypic analysis of ataxiain spinocerebellar ataxia type 6 mice using DeepLabCut.
Scientific Reports 14, 8571 (2024)
doi: 10.1038/s41598-024-59187-0



Rybarski M,  Mrohs D,  Osenberg K, Hemmersbach M, Pfeffel K,  Steinkamp J,  Schmidt D, Violou K, Schäning R,  Schmidtke K, Bader V,  Andriske M,  Bohne P, Mark MD,  Winklhofer KF,  Lübbert H,  Zhu X-R (2023)
Loss of parkin causes endoplasmic reticulum calcium dyshomeostasis by upregulation of reticulocalbin 1.
Eur J Neurosci 2023 Mar;57(5):739-761. doi: 10.1111/ejn.15917. Epub 2023 Feb 3.



Mrohs D*, Rybarski M*, Andriske M, Bohne P, Mark MD, Lübbert H, Zhu X (2022)
Additional polgD257Amutation (mutator) does not influence dopaminergic neurodegeneration in aged parkin-deficient mice.
Aging Pathobiology and Therapeutics. 5: DOI: 10.31491/APT.2023.03.106.
*Equal contribution.

Surdin T, Preissing B, Rohr L, Grömmke M, Böke H, Barcik M, Azimi Z, Jancke D, Herlitze S, Mark MD, Siveke I (2022)
Optogenetic activation of mGluR1 signaling in the cerebellum induces synaptic plasticity.
iScience 2022 Dec 17;26(1):105828 DOI: 10.1016/j.isci.2022.105828

Mark MD, Schwitalla JC, Herlitze S (2022)
Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengers.
Part II, p161-194. Book Chapter in: Zamponi GW, Weiss N (eds), Voltage-Gated Calcium Channels,
Book Chapter

Divvela SSK, Offei EB, Suerland F, García DR, Kwiatkowski J, Balakrishnan-Renuka A, Bohne P, Böing M, Morosan-Puopolo G, Mark MD, Brand-Saberi B (2022)
Atonal homolog 8/Math6 regulates differentiation and maintenance of skeletal muscle
Front. Cell Dev. Biol.10:950414.doi: 10.3389/fcell.2022.950414

Schwitalla JC, Pakusch J, Mücher B, Brückner A, Depke DA, Fenzl T, De Zeeuw CI, Kros L, Hoebeek FE, Mark MD (2022)
Controlling absence seizures from the cerebellar nuclei via activation of the G q signaling pathway.
Cell Mol Life Sci 2022 Mar 19;79(4):197. doi: 10.1007/s00018-022-04221-5.

Bohne P, Volkmann A, Schwarz MK, Mark MD (2022)
Deletion of the P/Q-type calcium channel from serotonergic neurons drives male aggression in mice
Journal of Neuroscience 19 July 2022, JN-RM-0204-22;

Mark, MD., Pakusch, J., Ernst, T.M., Timmann, D. (2022).
Cerebellum and Emotion Memory.
In: Adamaszek, M., Manto, M., Schutter, D.J.L.G. (eds) The Emotional Cerebellum . Advances in Experimental Medicine and Biology, vol 1378. Springer,
Chapter of the Advances in Experimental Medicine and Biology

Bohne P, Rybarski, M Mourabit DB, Krause F, Mark MD. (2022)
Cerebellar contribution to threat probability in a SCA6 mouse model.
Hum Mol Genet. doi: 10.1093/hmg/ddac135.



Bohne P, Mourabit DB, Josten M, Mark MD (2021)
Cognitive deficits in episodic Ataxia type 2 mouse models.
Hum Mol Genet. 2021 Jun 2:ddab149. doi: 10.1093/hmg/ddab149. Online ahead of print. PMID: 34077522

Karapinar R*, Schwitalla JC*, Eickelbeck D*, Pakusch J, Mücher B, Grömmke M, Surdin T, Knöpfel T, Mark MD*, Siveke I, Herlitze S* (2021)
Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks.
Nat Commun. 2021 Jul 23;12(1):4488. doi: 10.1038/s41467-021-24718-0. PMID: 34301944 *equal contributions

Romeo R, Boden-El Mourabit D, Scheller A, Mark MD, Faissner A (2021)
Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) as a Novel Regulator of Early Astroglial Differentiation.
Front Cell Neurosci. 2021 Feb 18;15:642521. doi: 10.3389/fncel.2021.642521. eCollection 2021. PMID: 33679332
Free PMC article

Hamad MIK, Jbara A, Rabaya O, Petrova P, Daoud S, Melliti N, Meseke M, Lutz D, Petrasch-Parwez E, Schwitalla JC, Mark MD, Herlitze S, Reiss G., Herz J, Förster E (2021)
Reelin modulates GABAB receptor function in the neocortex.
J. of Neurochemistry. DOI: 10.1111/jnc.14990



Bres EE, Safina D, Müller J, Bedner P, Yang H, Helluy X, Shchyglo O, Jansen S, Mark MD, Esser A, Steinhäuser C, Herlitze S, Pietrzik CU, Sirko S, Manahan-Vaughan D, Faissner A (2020)
Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures.
Glia. 2020 Dec;68(12):2517-2549. doi: 10.1002/glia.23869. Epub 2020 Jun 24. PMID: 32579270

Azimi Z, Barzan R, Spoida K, Surdin T, Wollenweber P, Mark MD, Herlitze S, Jancke D (2020)
Separable Gain Control of Ongoing and Evoked Activity in the Visual Cortex by Serotonergic Input
PMID: 32252889 , PMICD: PMC7138610, DOI: 10.7554/eLife.53552

Marquitan M, Ruff A, Bramini M, Herlitze S, Mark MD, Schuhmann W (2020)
Polymer/Enzyme-modified HF-etched carbon nanoelectrodes for single-cell analysis.
Bioelectrochemistry. DOI: 10.1016/j.bioelechem.2020.107487

Hellinger J, Jägers P, Spoida K, Weiss LC, Mark MD, Herlitze S (2020)
Analysis of the territorial aggressice behavior of the bioluminescent flashlight fish Photoblepharon steinitizi in the Red Sea.
Front. Mar. Sci. 7:78. doi: 10.3389/fmars.2020.00078

Miao QL, Herlitze S, Mark MD, Noebels JL (2020)
Adult Loss of Cacna1a in Mice Recapitulates Childhood Absence Epilepsy by Distinct Thalamic Bursting Mechanisms. Brain. 143(1): 161-174.

Marquitan M, Mark MD, Ernst A, Muhs A, Herlitze S, Ruff A and Schuhmann W (2020)
Glutamate detection at the cellular level by means of polymer/enzyme multilayer modified carbon nanoelectrodes.
Journal of Materials Chemistry B. DOI: 10.1039/c9tb02461a



Eickelbeck D, Karapinar R, Jack A, Suess ST, Barzan R, Azimi Z, Surdin T, Grömmke M, Mark MD, Gerwert K, Jancke D, Wahle P, Spoida K, Herlitze S. (2019)
CaMello-XR enables visualization and optogenetic control of Gq/11 signals and receptor trafficking in GPCR-specific domains.
Commun Biol. 2019 Feb 14;2:60. doi: 10.1038/s42003-019-0292-y. eCollection 2019. PMID: 30793039

Fekete A, Nakamura Y, Yang YM, Herlitze S, Mark MD, DiGregorio DA, Wang LY. (2019)
Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules.
Nat Commun. 2019 Feb 18;10(1):826. doi: 10.1038/s41467-019-08452-2. PMID: 30778063

Mark MD, Wollenweber P, Gesk A, Kösters K, Batzke K, Janoschka C, Maejima T, Han J, Deneris ES, Herlitze S. (2019)
RGS2 drives male aggression in mice via the serotonergic system
Commun Biol. 2019 Oct 11;2:373. doi: 10.1038/s42003-019-0622-0. eCollection 2019.

Eickelbeck D, Rudack T, Tennigkeit SA, Surdin T, Karapinar R, Schwitalla JC, Mücher B, Shulman M, Scherlo M, Althoff P, Mark MD, Gerwert K, Herlitze S. (2019)
Lamprey Parapinopsin ("UVLamP"): a Bistable UV-Sensitive Optogenetic Switch for Ultrafast Control of GPCR Pathways.
Chembiochem. 2019 Aug 29. doi: 10.1002/cbic.201900485. [Epub ahead of print]

Bohne P, Schwarz MK, Herlitze S, Mark MD. (2019)
A New Projection From the Deep Cerebellar Nuclei to the Hippocampus via the Ventrolateral and Laterodorsal Thalamus in Mice.
Front Neural Circuits. 2019 Aug 9;13:51. doi: 10.3389/fncir.2019.00051. eCollection 2019.

Tennigkeit SA, Karapinar R, Rudack T, Dreier MA, Althoff P, Eickelbeck D, Surdin T, Grömmke M, Mark MD, Spoida K, Lübben M, Höweler U, Herlitze S, Gerwert K. (2019)
Design of an Ultrafast G Protein Switch Based on a Mouse Melanopsin Variant.
Chembiochem. 2019 Jul 15;20(14):1766-1771. doi: 10.1002/cbic.201900110. Epub 2019 Jun 18.



Mark MD, Donner M, Eickelbeck D, Stepien J, Nowrousian M, Kück U, Paris F, Hellinger J, Herlitze S. (2018)
Visual tuning in the flashlight fish Anomalops katoptron to detect blue, bioluminescent light.
PLoS One. 2018 Jul 11;13(7):e0198765. doi: 10.1371/journal.pone.0198765. eCollection 2018. PMID: 29995896



Hellinger J, Jägers P, Donner M, Sutt F, Mark MD, Senen B, Tollrian R, Herlitze S. (2017)
The Flashlight Fish Anomalops katoptron Uses Bioluminescent Light to Detect Prey in the Dark.
PLoS One. 2017 Feb 8;12(2):e0170489. doi: 10.1371/journal.pone.0170489. eCollection 2017.
PMID: 28178297

Mark MD, Schwitalla JC, Groemmke M, Herlitze S. (2017)
Keeping Our Calcium in Balance to Maintain Our Balance.
Biochem Biophys Res Commun. Invited Review. 483: 1040-1050.



Marquitan M, Clausmeyer J, Actis P, Córdoba AL, Korchev Y, Mark MD, Herlitze S and Schuhmann W (2016)
Intracellular Hydrogen Peroxide Detection with Functionalised Nanoelectrodes.
ChemElectroChem. 24 AUG 2016 | DOI: 10.1002/celc.201600390.

Spoida K, Eickelbeck D, Karapinar R, Eckhardt, T, Mark MD, Jancke D, Ehinger BV, König P, Dalkara D, Herlitze S, Masseck OA. (2016)
Melanopsin Variants as Intrinsic Optogenetic On and Off Switches for Transient versus Sustained Activation of G Protein Pathways.
Current Biology 26 (9), 1206–1212

Bomben VC, Aiba I, Qian J, Mark MD, Herlitze S, Noebels JL (2016)
Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.
J Neurosci. 2016 Jan 13;36(2):405-18. doi: 10.1523/JNEUROSCI.2555-15.2016.
PMID: 26758833



Mark MD, Krause M, Boele HJ, Kruse W, Pollok S, Kuner T, Dalkara D, Koekkoek S, De Zeeuw CI, Herlitze S. (2015)
Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity.
J Neurosci. Jun 10;35(23):8882-8895. doi: 10.1523/JNEUROSCI.0891-15.2015.



Kruse W, Krause M, Aarse J, Mark MD, Manahan-Vaughan D, Herlitze S. (2014)
Optogenetic Modulation and Multi-Electrode Analysis of Cerebellar Networks In Vivo.
DOI: 10.1371/journal.pone.0105589

Masseck OA, Mark MD, Herlitze S (2014)
Use of Optogenetic Approaches to Control Intracellular Signaling of G Protein-Coupled Receptors. G-Protein Coupled Receptor Genetics.
Methods in Pharmacology and Toxicology pp. 149-160. Springer Verlag Book Chapter.



Maejima T, Wollenweber P, Teusner LUC, Noebels JL, Herlitze S, Mark MD. (2013)
Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to Purkinje Cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice.
The Journal of Neuroscience, doi: 10.1523/JNEUROSCI.5442-12.2013

Maejima T, Masseck OA, Mark MD, Herlitze S (2013)
Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channels.
Front Integr Neurosci. 23:7-40, doi: 10.3389/fnint.2013.00040



Mark M, Maejima T, Kuckelsberg D, Yoo J, Hyde R, Shah V, Gutierrez D, Moreno R, Kruse W, Noebels J , Herlitze S. (2011)
Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1A mutations.
J. Neurosci. 31:4311-4326.

Gutierrez DV, Mark MD, Masseck O, Maejima T, Kuckelsberg D, Hyde RA, Krause M, Kruse W, Herlitze S.(2011)
Optogenetic control of motor coordination by Gi/o protein-coupled vertebrate rhodopsin in cerebellar.
J Biol Chem. 286:25848-25858.



Xie M, Li X, Han J, Vogt DL, Wittemann S, Mark MD, Herlitze S. (2007)
Facilitation versus depression in cultured hippocampal neurons determined by targeting of Ca2+ channel Cavbeta4 versus Cavbeta2 subunits to synaptic terminals.
J Cell Biol. 2007 Jul 30;178(3):489-502



Han J, Mark MD, Li X, Xie M, Waka S, Rettig J, Herlitze S. (2006)
RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi/o-mediated inhibition of presynaptic Ca2+ channels.
Neuron. 2006 Sep 7;51(5):575-586.



Li X, Gutierrez DV, Hanson MG, Han J, Mark MD, Chiel H, Hegemann P, Landmesser LT, Herlitze S. (2005)
Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin.
Proc Natl Acad Sci U S A. 2005 Dec 6; 102(49):17816-17821.

Herlitze S, Mark, MD. (2005)
Distribution and targeting of Ca2+ channels. Book Title:Voltage-gated Calcium Channels,
Editor: Gerald Zamponi, Chapter 7, 113-140, Kluwer Academic Plenum Publ., ISBN: 0-306-47840-4.



Herlitze S, Xie M, Han J, Hümmer A, Melnik-Martinez KV, Moreno RL, Mark MD. (2003)
Targeting mechanisms of high voltage-activated Ca2+ channels.
J Bioenerg Biomembr. 2003 Dec; 35(6):621-637.

Hümmer A, Delzeith O, Gomez SR, Moreno RL, Mark MD, Herlitze S. (2003)
Competitive and synergistic interactions of G protein beta(2) and Ca(2+) channel beta(1b) subunits with Ca(v)2.1 channels, revealed by mammalian two-hybrid and fluorescence resonance energy transfer measurements.
J Biol Chem. 2003 Dec 5; 278(49):49386-49400.



Mark MD, Wittemann S, Herlitze S. (2000)
G protein modulation of recombinant P/Q-type calcium channels by regulators of G protein signalling proteins.
J Physiol. 2000 Oct 1; 528: 64-77.

Mark MD, Herlitze S. (2000)
G-protein mediated gating of inward-rectifier K+ channels.
Eur J Biochem. 2000 Oct; 267(19):5830-5836.

Mark MD, Ruppersberg JP, Herlitze S. (2000)
Regulation of GIRK channel deactivation by Galpha(q) and Galpha(i/o) pathways.
Neuropharmacology. 2000 Sep; 39(12):2360-2373.

Wittemann S, Mark MD, Rettig J, Herlitze S. (2000)
Synaptic localization and presynaptic function of calcium channel beta 4-subunits in cultured hippocampal neurons.
J Biol Chem. 2000 Dec 1; 275(48):37807-37814.



Herlitze S, Ruppersberg JP, Mark MD. (1999)
New roles for RGS2, 5 and 8 on the ratio-dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes.
J Physiol. 1999 Jun 1; 517 ( Pt 2):341-352.



Mark MD, Lohrum M., Püschel, AW. (1997)
Patterning neuronal connections by chemorepulsion: the semaphorins.
Cell and Tissue Res. 290(2): 299-306.

Mark MD, Storm DR. (1997)
Antiproliferative activity of KCl contributes to EGF-induced neurite outgrowth in PC12 cells.
Neurosci. Lett. 230(2): 73-76.

Mark MD, Storm DR. (1997)
Coupling of Epidermal Growth Factor (EGF) with the antiproliferative activity of cAMP induces neuronal differentiation.
J Biol Chem. 272: 17238-17244.



Impey S, Mark M, Villacres EC, Poser S, Chavkin C, Storm DR. (1996)
Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus.
Neuron. 16: 973-982.



Mark MD, Liu Y, Wong ST, Hinds T, Storm DR. (1995)
Stimulation of neurite outgrowth in PC12 cells by EGF and KCl depolarization: A Ca2+ independent phenomenon.
Journal of Cell Biology. 130: 701-710.