Unlike conventional light-controllable proteins, the newly characterized optogenetic tool can be switched off, not switched on, by light. It could be suitable for investigating the basic principles of epilepsy.
(Picture: Some of the Bochum researchers: Melanie Mark, Johanna Pakusch, Jan Claudius Schwitalla, Stefan Herlitze, Ida Siveke)
This recorded interview is the third in our Interviews with Experts series and features Stefan Herlitze, PhD, Neuroscientist and Faculty of Biology and Biotechnology at Ruhr-Universität Bochum, Germany.
In order for the egg and sperm cells of corals from different colonies to intermingle, the individuals of one species must spawn at the same time. But how do they manage to synchronise it?
(Picture: Mareike Huhn during one of her dives. With the help of a magnifying glass, she tries to identify the coral species more closely.
Batsikadze G*, Pakusch J*, Klein M, Ernst TM, Thieme A, Nicksirat SA, Steiner KM, Nio E, Genc E, Maderwald S, Deuschl C, Merz CJ, Quick HH, Mark MD*, Timmann D* (2024)
Mild deficits in fear learning: Evidence from humans and mice with cerebellar cortical degeneration.
eNeuro. 2024 Jan 4:ENEURO.0365-23.2023. doi: 10.1523/ENEURO.0365-23.2023. Online ahead of print.
*Equal contribution.
Abstract
Krause F, Schmidtke K, de Vasconcelos MF, Schmidt D, Cansiz B, Theisen F, Mark MD, Rybarski MO.
A shedding analysis after AAV8 CNS injection revealed fragmented viral DNA without evidence of functional AAV particles in mice.
Gene Ther. 2024 Mar 12. doi: 10.1038/s41434-024-00447-z. Epub ahead of print.
Deane KE, Klymentiev R, Heck J, Mark MD, Ohl FW, Heine M, Happel MFK (2024)
Inhibiting presynaptic calcium channel motility in the auditory cortex suppresses synchronized input processing.
Front. Cell. Neurosci., 10 April 2024 Sec. Cellular Neurophysiology Volume 18 – 2024
doi: 10.3389/fncel.2024.1369047
Article
Piotrowski D, Clemensson EKH, Nguyen HP, Mark MD (2024)
Phenotypic analysis of ataxiain spinocerebellar ataxia type 6 mice using DeepLabCut.
Scientific Reports 14, 8571 (2024)
doi: 10.1038/s41598-024-59187-0
Article
Rybarski M, Mrohs D, Osenberg K, Hemmersbach M, Pfeffel K, Steinkamp J, Schmidt D, Violou K, Schäning R, Schmidtke K, Bader V, Andriske M, Bohne P, Mark MD, Winklhofer KF, Lübbert H, Zhu X-R (2023)
Loss of parkin causes endoplasmic reticulum calcium dyshomeostasis by upregulation of reticulocalbin 1.
Eur J Neurosci 2023 Mar;57(5):739-761. doi: 10.1111/ejn.15917. Epub 2023 Feb 3.
Abstract
PUBLICATIONS 2022
Mrohs D*, Rybarski M*, Andriske M, Bohne P, Mark MD, Lübbert H, Zhu X (2022)
Additional polgD257Amutation (mutator) does not influence dopaminergic neurodegeneration in aged parkin-deficient mice.
Aging Pathobiology and Therapeutics. 5: DOI: 10.31491/APT.2023.03.106.
*Equal contribution.
Süß ST, Olbricht LM, Herlitze S, Spoida K. (2022)
Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway.
Transl Psychiatry. 2022 Nov 19. DOI: 10.1038/s41398-022-02252-x.
Article
News RUB
Mark MD, Schwitalla JC, Herlitze S (2022)
Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengers.
Part II, p161-194. Book Chapter in: Zamponi GW, Weiss N (eds), Voltage-Gated Calcium Channels. Springer.
Book Chapter
N. Stangier, S. Sandhöfer, A. Mosig and C. Distler
The uropygial gland of the Great Cormorant (Phalacrocorax carbo): I. Morphology.
Journal of Ornithology Accepted: 21 December 2022, doi.org/10.1007/s10336-022-02042-8
Article
Surdin T, Preissing B, Rohr L, Grömmke M, Böke H, Barcik M, Azimi Z, Jancke D, Herlitze S, Mark MD, Siveke I (2022)
Optogenetic activation of mGluR1 signaling in the cerebellum induces synaptic plasticity.
iScience 2022 Dec 17;26(1):105828 DOI: 10.1016/j.isci.2022.105828
Artical
News RUB
Divvela SSK, Offei EB, Suerland F, García DR, Kwiatkowski J, Balakrishnan-Renuka A, Bohne P, Böing M, Morosan-Puopolo G, Mark MD, Brand-Saberi B (2022)
Atonal homolog 8/Math6 regulates differentiation and maintenance of skeletal muscle
Front. Cell Dev. Biol.10:950414.doi: 10.3389/fcell.2022.950414
Schwitalla JC, Pakusch J, Mücher B, Brückner A, Depke DA, Fenzl T, De Zeeuw CI, Kros L, Hoebeek FE, Mark MD (2022)
Controlling absence seizures from the cerebellar nuclei via activation of the G q signaling pathway.
Cell Mol Life Sci 2022 Mar 19;79(4):197. doi: 10.1007/s00018-022-04221-5.
Abstract
Bohne P, Volkmann A, Schwarz MK, Mark MD (2022)
Deletion of the P/Q-type calcium channel from serotonergic neurons drives male aggression in mice
Journal of Neuroscience 19 July 2022, JN-RM-0204-22;
DOI: https://doi.org/10.1523/JNEUROSCI.0204-22.2022
Abstract
Mark, MD., Pakusch, J., Ernst, T.M., Timmann, D. (2022).
Cerebellum and Emotion Memory.
In: Adamaszek, M., Manto, M., Schutter, D.J.L.G. (eds) The Emotional Cerebellum . Advances in Experimental Medicine and Biology, vol 1378. Springer,
Cham. https://doi.org/10.1007/978-3-030-99550-8_5
Chapter of the Advances in Experimental Medicine and Biology
Bohne P, Rybarski, M Mourabit DB, Krause F, Mark MD. (2022)
Cerebellar contribution to threat probability in a SCA6 mouse model.
Hum Mol Genet. doi: 10.1093/hmg/ddac135.
Abstract
Mark MD, Schwitalla JC, Herlitze S (2022)
Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengers.
Part II, p161-194. Book Chapter in: Zamponi GW, Weiss N (eds), Voltage-Gated Calcium Channels. Springer.
Book Chapter
P. Wahle, E. Sobierajski, I. Gasterstädt, N. Lehmann, S. Weber, J. HR Lübke, M. Engelhardt, C. Distler and G. Meyer
Neocortical pyramidal neurons with axons emerging from dendrites are frequent in non- primates, but rare in monkey and human
eLife 2022;11:e76101. DOI: https://doi.org/10.7554/eLife.76101
Article
J. van Kempen, C. Brandt2, C. Distler, M. A. Bellgrove5 and A. Thiele
Dopamine influences attentional rate modulation in Macaque posterior parietal cortex
Scientific Reports | (2022) 12:6914-w
https://doi.org/10.1038/s41598-022-10634-w
www.nature.com/scientificreports
Article
Copyright © neurobiol 2024
Last update: Apr 15, 2024
